Author: Gudisa Bereda

Abstract:

Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous units, which affects the majority of individuals at some time in their lives, usually during adolescence. Acne is a disorder of the sebaceous follicles, which are special pilosebaceous units located on the face, neck, chest, upper back, and upper arms. These units consist of relatively large sebaceous glands associated with small hair follicles. Inflammation is a direct or indirect result of P acnes proliferation. Follicular rupture and extension of inflammation into the dermis result in formation of the inflammatory lesions of acne vulgaris papules, pustules, and nodules. Retinoids (isotretinoine) is the only drug which acts on the four main factors in acne and is considered a revolution in treatment of acne. While is used commonly especially in problematic types like classical acnes, it may also be currently used in persistent moderate classical acnes which lead to psychological problems. They decrease production of sebum, inactivate sebaceous glands with active inflammation and reduce them. They change the structure of lipids. They indirectly reduce the number of bacteriae by decreasing the amount of sebum.