Diabetes is on the rise and India is one of the top 10 in the prevalence table according to WHO. In post covid it is steadily increasing everywhere and has become a rising risk for healthcare globally. Diabetes is a metabolic disorder characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Recent studies show that diabetes is caused by impairment of the immune system, which has already been explored as one of the reasons causing Prameha in Ayurveda. Prameha maybe considered as a metabolic syndrome that includes clinical conditions and the primary goal in managing diabetes should not be merely to achieve normoglycemia but also to minimize the complications. In this context, Ayurvedic treatment can be considered to effectively manage diabetes. Methodology: A 63year male was suffering from frequent urination associated with increased appetite, burning sensation of palms and foot and lethargy. He was diagnosed with Diabetes mellitus with Hba1c of 12.5. The treatment protocol comprised of herbomineral internal medications and Panchakarma procedures. Results: At the end of the treatment, HbA1c was reduced to 6.5 from 12.5, and significant reduction in other parameters as well as symptoms were noted. Discussion: Prameham occurs due to Kapha Vata Medo Dushti, and most of the medicines given have Vatakaphahara and Madhura-Katu Vipaka. Conclusion: The global burden of DM is reaching potentially high and morbidity and mortality rate becomes higher even though in this high-standards medical era, hence an attempt is made to reduce the burden through Ayurveda Samana chikitsa.