Title: FORMULATION AND EVALUATION OF LORNOXICAM EXTENDED-RELEASE TABLETS
Authors: Prince Joshi Bollam, Munija Pancheddula, K. Durga Mounika, B. Shailaja and Srujana Raparti
Abstract:

The aim of the present study was to develop Extended-release formulation of Lornoxicam to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC K100M, HPMC (K4M) and Carbopol 71 G were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 98.85% in 12 hours. It contains the HPMC (K4M) as Extended-release material. It followed Peppas release kinetics mechanism.

Keywords: Lornoxicam, HPMC (K4M), HPMC K100M, Carbopol 71 G, Extended-release system.
DOI: https://doi.org/10.61646/IJCRAS.vol.4.issue1.110
Date of Publication: 31-01-2025
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Published Volume and Issue: Volume 4 Issue 1 Jan-Feb 2025